AMERICAN GINSENG: SIDE EFFECT & SAFETY

American ginseng is LIKELY SAFE when taken by mouth appropriately, short-term. Doses of 100-3000 mg daily have been used safely for up to 12 weeks. Single doses of up to 10 grams have also been safely used. In addition, a specific American ginseng extract called CVT-E002 (Cold-FX, Afexa Life Sciences, Canada) has also been used safely for up to 4 months.

When taken by mouth, American ginseng can cause some side effects including diarrhea, itching, trouble sleeping (insomnia), headache, and nervousness. In some people, American ginseng might also cause rapid heartbeat, increased blood pressure or decreased blood pressure, breast tenderness, vaginal bleeding in women, and other side effects. Uncommon side effects that have been reported include a severe rash called Stevens-Johnson syndrome, liver damage, and severe allergic reaction.



Special Precautions & Warnings:



Children: American ginseng is POSSIBLY SAFE for children when taken by mouth appropriately, short-term. A specific American ginseng extract called CVT-E002 (Cold-FX, Afexa Life Sciences, Canada) has been used in doses of 4.5-26 mg daily for 3 days in children 3-12 years-old.



Pregnancy and breast-feeding: American ginseng is POSSIBLY UNSAFE in pregnancy. One of the chemicals in Panax ginseng, a plant related to American ginseng, has been linked to possible birth defects. Do not take American ginseng if you are pregnant.



There is not enough reliable information about the safety of taking American ginseng if you are breast feeding. Stay on the safe side and avoid use.



Diabetes: American ginseng might lower blood sugar. In people with diabetes who are taking medications to lower blood sugar, adding American ginseng might lower it too much. Monitor your blood sugar closely if you have diabetes and use American ginseng.



Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: American ginseng preparations that contain chemicals called ginsenosides might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use American ginseng that contains ginsenosides. However, some American ginseng extracts have had the ginsenosides removed (Cold-fX, Afexa Life Sciences, Canada). American ginseng extracts such as these that contain no ginsenosides or contain only a low concentration of ginsenosides do not appear to act like estrogen.



Trouble sleeping (insomnia): High doses of American ginseng have been linked with insomnia. If you have trouble sleeping, use American ginseng with caution.



Schizophrenia (a mental disorder): High doses of American ginseng have been linked with sleep problems and agitation in people with schizophrenia . Be careful when using American ginseng if you have schizophrenia.



Surgery: American ginseng might affect blood sugar levels and might interfere with blood sugar control during and after surgery. Stop taking American ginseng at least 2 weeks before a scheduled surgery.

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AMERICAN GINSENG: DOSING

The following doses have been studied in scientific research:



BY MOUTH:

For reducing blood sugar in people with type 2 diabetes: 3 grams up to 2 hours before a meal. American ginseng should be taken within 2 hours of a meal. If it is taken too long before eating, the blood sugar might become too low.100-200 mg of American ginseng have been taken daily for up to 8 weeks.

For preventing upper respiratory tract infections such as the common cold or flu: a specific American ginseng extract called CVT-E002 (Cold-fX, Afexa Life Sciences, Canada) 200 mg twice daily for 3-4 months has been used.

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Ginseng Could Decrease Cancer-Related Fatigue: Study

A gnarled-looking root could be a natural way of quelling fatigue in cancer patients, according to new research.

Cancer patients who took high doses of American ginseng over a two-month period experienced less fatigue than people who were given a placebo, according to the study, conducted by Mayo Clinic researchers.

The study, presented at the annual meeting of the American Society of Clinical Oncology, included 340 people who were either currently undergoing cancer treatments, or who had just completed cancer treatments. Every day, each person was given either a placebo pill or a pill that contained 2,000 milligrams of American ginseng root.



The researchers found that at the end of eight weeks, the people who were given ginseng had fewer symptoms of fatigue and tiredness compared with the people given the placebo.



"After eight weeks, we saw a 20-point improvement in fatigue in cancer patients, measured on a 100-point, standardized fatigue scale," study researcher Debra Barton, Ph.D., of the Mayo Clinic Cancer Center, said in a statement.



The ginseng given to the patients in the study was pure American ginseng root that had been ground up and put in capsule form. Barton noted that ginseng that is purchased off-the-shelf may be dangerous for people with breast cancer because ethanol is sometimes used to process it, "which can give it estrogen-like properties that may be harmful to breast cancer patients."



The University of Maryland Medical Center pointed out that research has shown other beneficial effects of American ginseng; it's been found to decrease levels of blood sugar in people with Type 2 diabetes, and in a lab study on cells, it's been found to stop colorectal cancer cell growth. Ginseng also seems to decrease cold duration and boost the immune system.



However, the University of Maryland Medical Center warns that people should consult their doctors before taking ginseng as it can cause a number of side effects, from headache and vomiting, to insomnia and high blood pressure. There are also certain people for whom ginseng could be dangerous.

www.huffpost.com

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One cancer treatment that reduces cancer fatigue is Ginseng, Mayo Clinic study finds

Fatigue is one of the most common effects of cancer and cancer treatment.



Now, cancer-related fatigue appears to have an enemy. A Mayo Clinic study found that high doses of the herb ginseng was effective in reducing cancer-related fatigue over two months when compared with a placebo.



Mayo Researchers evaluated 340 patients who had either completed cancer treatment or were undergoing treatment at one of 40 community medical centers. Study participants would receive a daily dosage of a placebo or 2,000 milligrams of ginseng administered in capsules containing pure, ground American ginseng root.



That is markedly different from off-the-shelf ginseng, which sometimes is processed with ethanol, giving it characteristics similar to estrogen. That is harmful for breast cancer patients, warned researcher Debra Barton of the Mayo Clinic Cancer Center, in a Mayo news release.



Ginseng’s effect on fatigue showed marked improvement over time from a slight improvement at four weeks to significant improvement at eight weeks.



“After eight weeks, we saw a 20-point improvement in fatigue in cancer patients, measured on a 100-point, standardized fatigue scale,” Barton said.



Barton and other researchers could find no apparent side effects from the herb.



Aside from reducing fatigue, American ginseng also appears to have other cancer-fighting abilities. According to a 2010 lab study, American ginseng extract led cultures of colorectal cancer cells to die, implying that the herb may have an anticancer properties.

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